名稱 | ADCC Bioassay Effector Cell F variant (Low Affinit |
型號 | CBP74002 |
報價 | ![]() |
特點 | ADCC Bioassay Effector Cell F variant (Low Affinity)- Fcγ-NFAT/Jurkat,母細胞:Jurkat,培養基:1640+10%FBS |
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藥靶星空体育官方网站首页 > 腫瘤免疫星空体育官方网站首页 > CBP74002ADCC Bioassay Effector Cell F variant (Low Affinit

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I. Background | |
抗體(ti) 依賴的細胞介導的細胞毒性作用(ADCC,antibody-dependent cell-mediated cytotoxicity )是指抗體(ti) 的 Fab 段結合病毒感染的細胞或腫瘤細胞的抗原表位,其 Fc 段與(yu) 殺 傷(shang) 細胞(NK 細胞、巨噬細胞等)表麵的 FcR 結合,介導殺傷(shang) 細胞直接殺傷(shang) 靶細胞,它是 抗腫瘤的治療性抗體(ti) 藥物發生作用的一種作用重要機製。 | |
II. Description | |
ADCC Bioassay Effector Cell F variant (Low Affinity)-Fcγ-NFAT Jurkat 報告基因藥靶模型 很好的模擬了體(ti) 內(nei) ADCC 的信號轉導過程,原理見下圖所示。
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III. Introduction | |
Host Cell: | Jurkat |
Expressed gene: | NFAT-Luc-CD16(F158) |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Synonym(s): | Antibody-dependent cell-mediated cytotoxicity |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | RPMI-1640+10%FBS |
Mycoplasma Testing: | Negative |
Storage: | Immediately upon receipt, store in liquid nitrogen. |
Application(s): | Functional(Report Gene) Assay |
IV. Description of Host Cell Line | |
Organism: | Homo sapiens, human |
Tissue: | Peripheral blood |
Disease: | Acute T cell leukemia |
Morphology: | Lymphoblast |
Growth Properties: | Suspension |
Ⅴ. Representative Data |
Figure 2. Recombinant ADCC Bioassay Effector Cell F variant (Low Affinity)- Fcγ-NFAT/Jurkat expressing CD16.
Figure 3. Dose response of CD20 Ab in ADCC Bioassay Effector Cell F variant (Low Affinity)-Fcγ-NFAT Jurkat (C11) with Raji.